ilexgenin A
| Name | Ilexgenin A | ||
| PubChem CID | 21672638 | ||
| Molecular Weight | 502.7g/mol | ||
| Synonyms |
ilexgenin A |
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| Formula | C₃₀H₄₆O₆ | ||
| SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C(=O)O)O)C)C)C2C1(C)O)C)C(=O)O | ||
| InChI | 1S/C30H46O6/c1-17-9-14-30(24(34)35)16-15-26(3)18(22(30)29(17,6)36)7-8-19-25(2)12-11-21(31)28(5,23(32)33)20(25)10-13-27(19,26)4/h7,17,19-22,31,36H,8-16H2,1-6H3,(H,32,33)(H,34,35)/t17-,19-,20-,21+,22-,25-,26-,27-,28-,29-,30+/m1/s1 | ||
| InChIKey | UIEGOKVPCRANSU-XUFMHOFVSA-N | ||
| CAS Number | 108524-94-3 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ShanLvCha | ||
| Use Part | Tender leaf or tender bud | ||
| Flavor | Sweet; Bitter | ||
| Meridian Tropism | Lung; Stomach; Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Aquifoliales
-->Family: Aquifoliaceae
-->Genus: Ilex
-->Species: Ilex hainanensis
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| Pair Name | Ilexgenin A, Sorafenib | |||
| Partner Name | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Up-regulation | Expression | CASP3 | hsa836 |
| Up-regulation | Expression | CASP7 | hsa840 | |
| Down-regulation | Expression | IL6 | hsa3569 | |
| Down-regulation | Expression | MVD | hsa4597 | |
| Down-regulation | Expression | PIK3CA | hsa5290 | |
| Down-regulation | Expression | STAT3 | hsa6774 | |
| Down-regulation | Expression | TNF | hsa7124 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | The results described in the present study identifies Ilexgenin A as a promising therapeutic candidate that modulates inflammation, angiogenesis, and HCC growth. | |||
